A case of multiple sclerosis presenting with inflammatory cortical demyelination
نویسندگان
چکیده
منابع مشابه
Inflammatory cortical demyelination in early multiple sclerosis.
BACKGROUND Cortical disease has emerged as a critical aspect of the pathogenesis of multiple sclerosis, being associated with disease progression and cognitive impairment. Most studies of cortical lesions have focused on autopsy findings in patients with long-standing, chronic, progressive multiple sclerosis, and the noninflammatory nature of these lesions has been emphasized. Magnetic resonanc...
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Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis pathology, only partially explain the patient's clinical deficits. We thus analysed global brain pathology in multiple sclerosis, focusing on the normal-appearing white matter (NAWM) and the cortex. Autopsy tissue from 52 multiple sclerosis patients (acute, relapsing-remitting, primary and secondary progres...
متن کاملA Case of Cortical Multiple Sclerosis.
Dear Editor, Multiple Sclerosis (MS) is a chronic progressive demyelina-ting disease of the central nervous system. Cognitive dysfunc-tion (CD) is usually observed at advanced stages of the disease but CD may be rarely observed at the initial stages of MS. Very unusually, MS presents primarily as CD; when this presentation occurs, it is referred as " cortical " or " cerebral " MS in the relevan...
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Osmotic demyelination syndrome is a demyelinating disorder associated with rapid correction of hyponatremia. But, it rarely occurs in acute hypernatremia, and it leads to permanent neurologic symptoms and is associated with high mortality. A 44-year-old woman treated with alternative medicine was admitted with a history of drowsy mental status. Severe hypernatremia (197mEq/L) with hyperosmolali...
متن کاملMeningeal inflammation is not associated with cortical demyelination in chronic multiple sclerosis.
Cortical demyelination can be extensive in chronic multiple sclerosis (MS) patients. Cortical lesions are not associated with lymphocyte infiltration, blood-brain barrier disruption, or complement deposition; therefore, their pathogenesis is unclear. We analyzed the extent and cellular composition of leptomeningeal inflammatory infiltrates and their relationship with cortical demyelinated lesio...
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ژورنال
عنوان ژورنال: Neurology
سال: 2011
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0b013e31821a44f1